change of BDNF expression in traumatic brain injury after Kaempferia galanga L. administration

BDNF has potent effects on neural synapses and its pathway affects cell survival other biological processes. Kaempferia galanga L. many active substances with antioxidant anti-inflammatory effects. We analyzes in four different group of Wistar rats (Ratus novergicus) into Groups A (no trauma & extract), B (with no C 600 mg/kgbw D 1200 extract). B, C, are further divided those who had their measured 24- (B24, C24, D24) 48-hours. expression were found to be statistically significant between Group both B24 (p = 0,009) D24 the 24-hour post-trauma decapitation analysis. On 48 hours after extract administration, B48 0,002), C48 <0,001), D48 <0,001) significantly A. The administration can considered as an option increasing brain levels which neuroprotective. Larger specific studies needed determine appropriate dose duration.